Methyl iodide → (4-Isopropoxy-phenyl)-(2-methyl-quinazolin-4-yl)-methyl-amine

反応式

[CH:1]([O:4][C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12]2[C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[N:15]=[C:14]([CH3:22])[N:13]=2)=[CH:7][CH:6]=1)([CH3:3])[CH3:2].[CH3:23]I>>[CH:1]([O:4][C:5]1[CH:6]=[CH:7][C:8]([N:11]([C:12]2[C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[N:15]=[C:14]([CH3:22])[N:13]=2)[CH3:23])=[CH:9][CH:10]=1)([CH3:3])[CH3:2]

参加物

反応物 2

HCID 6328Methyl iodide

HCID 57938805N-(4-Isopropoxyphenyl)-2-methylquinazolin-4-amine

生成物 1

HCID 11370251(4-Isopropoxy-phenyl)-(2-methyl-quinazolin-4-yl)-methyl-amine

実験手順

The title compound was prepared from (4-isopropoxy-phenyl)-(2-methyl-quinazolin-4-yl)-amine (164.3 mg, 0.56 mmol) and methyl iodide (0.25 ml, 3.92 mmol) by a procedure similar to example 7. 1H NMR (CDCl3): 7.73 (d, J=7.8 Hz, 1H), 7.54-7.49 (m, 1H), 7.10-6.86 (m, 6H), 4.57-4.52 (m, 1H), 3.58 (s, 3H), 2.72 (s, 3H), 1.36 (d, J=6 Hz, 6H).

出典と根拠

ORDレコード: ord-7e037647b32c4dadbbaf0729e0fa03a4
出典データセット: uspto-grants-2012_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08258145B2

反応ノート

読み込み中…

参加物