(RS)-S-(4-nitrophenyl)-N-(methylcarbamoyl)-S-methylsulfoximide → (RS)-S-(4-aminophenyl)-N-(methylcarbamoyl)-S-methylsulfoximide
反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([S:10]([CH3:17])(=[N:12][C:13](=[O:16])[NH:14][CH3:15])=[O:11])=[CH:6][CH:5]=1)([O-])=O>CO.[Pd]>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([S:10]([CH3:17])(=[N:12][C:13](=[O:16])[NH:14][CH3:15])=[O:11])=[CH:6][CH:5]=1参加物
4
実験手順
302 mg (1.17 mmol) (RS)—S-(4-nitrophenyl)-N-(methylcarbamoyl)-S-methylsulfoximide in 20 ml methanol is hydrogenated over 60 mg palladium (10% on carbon, 50% water wet) for 4 hours at 26° C. and 30 bar. The catalyst is filtered and the solvent evaporated to give 271 mg (corresponding to 100% of theor.) of the product.
後処理
- filtrationThe catalyst is filtered
- customthe solvent evaporated
- customto give 271 mg (corresponding to 100% of theor.) of the product
出典と根拠
- ORDレコード
- ord-960c30a9466b4919ad90f83963fd98bf
- 出典データセット
- uspto-grants-2014_02
- 特許番号
- US08642611B2
反応ノート
読み込み中…