Sodium Azide → Methyl[1-(3-azidopropyl)cyclopropyl]acetate
反応式
[CH3:1][O:2][C:3](=[O:12])[CH2:4][C:5]1([CH2:8][CH2:9][CH2:10]Br)[CH2:7][CH2:6]1.[N-:13]=[N+:14]=[N-:15].[Na+]>CN(C=O)C>[CH3:1][O:2][C:3](=[O:12])[CH2:4][C:5]1([CH2:8][CH2:9][CH2:10][N:13]=[N+:14]=[N-:15])[CH2:7][CH2:6]1参加物
4
実験手順
680 mg (2.89 mmol) of methyl[1-(3-bromopropyl)cyclopropyl]acetate and 1128 mg (17.35 mmol) of sodium azide in 5 ml of DMF were stirred at 60° C. for 2 h. The reaction mixture was then concentrated under reduced pressure. The residue was taken up in ethyl acetate and the solution was washed with saturated sodium chloride solution and dried over anhydrous magnesium sulfate. Removal of the solvent under reduced pressure gave 389 mg (1.97 mmol, 68% of theory) of the title compound as a yellow oil.
後処理
- concentrationThe reaction mixture was then concentrated under reduced pressure
- washthe solution was washed with saturated sodium chloride solution
- dry with materialdried over anhydrous magnesium sulfate
- customRemoval of the solvent under reduced pressure
出典と根拠
- ORDレコード
- ord-78b37aa043e64a5cb1534183f5ad0406
- 出典データセット
- uspto-grants-2014_02
- 特許番号
- US08642592B2
反応ノート
読み込み中…