Hydrochloric Acid → Methyl[1-(3-aminopropyl)cyclopropyl]acetate hydrochloride
反応式
[CH3:1][O:2][C:3](=[O:14])[CH2:4][C:5]1([CH2:8][CH2:9][CH2:10][N:11]=[N+]=[N-])[CH2:7][CH2:6]1.[ClH:15]>[Pd].C(O)C>[ClH:15].[CH3:1][O:2][C:3](=[O:14])[CH2:4][C:5]1([CH2:8][CH2:9][CH2:10][NH2:11])[CH2:6][CH2:7]1参加物
5
実験手順
At room temperature, a mixture of 389 mg (1.97 mmol) of methyl[1-(3-azidopropyl)cyclopropyl]acetate, 40 mg of 10% palladium on carbon and 1.97 ml (1.97 mmol) of 1 M hydrochloric acid in 10 ml of ethanol were hydrogenated under atmospheric pressure overnight. After the reaction had ended, the mixture was filtered and the filtrate was concentrated to dryness. This gave 313 mg (1.51 mmol, 76% of theory) of the title compound as a colorless oil.
後処理
- customwere hydrogenated under atmospheric pressure overnight
- filtrationthe mixture was filtered
- concentrationthe filtrate was concentrated to dryness
出典と根拠
- ORDレコード
- ord-77f1075bbca04348a8b55fa5af00fd99
- 出典データセット
- uspto-grants-2014_02
- 特許番号
- US08642592B2
反応ノート
読み込み中…