Hydroxyamine hydrochloride → 2,5-Dichloro-N-[2-(N-formyl-N-hydroxy-amino)-ethyl]-benzamide
反応式
[Cl:1][C:2]1[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][C:3]=1[C:4]([NH:6][CH2:7][CH:8]=O)=[O:5].Cl.[NH2:16][OH:17].[C:18]([O-:21])(=O)C.[Na+]>CO>[Cl:1][C:2]1[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][C:3]=1[C:4]([NH:6][CH2:7][CH2:8][N:16]([CH:18]=[O:21])[OH:17])=[O:5]参加物
5
実験手順
To a solution of 2,5-dichloro-N-(2-oxo-ethyl)-benzamide (0.67 g, 2.9 mmol) in MeOH (100 mL) was added hydroxylamine hydrochloride (0.41 g, 5.8 mmol) and sodium acetate (0.48 g, 5.8 mmol). The mixture was stirred 18 h and the MeOH was removed in vacuo. The residue was dried in vacuo for 18 h and used without further purification to provide the title compound (1.34 g) as a white solid. ESMS: M+H=247.
後処理
- customthe MeOH was removed in vacuo
- customThe residue was dried in vacuo for 18 h
- customused without further purification
出典と根拠
- ORDレコード
- ord-c118b164c23047279ae3bf0e65a4936f
- 出典データセット
- uspto-grants-2005_02
- 特許番号
- US06852882B2
反応ノート
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