Pyrrolo[3,2-b]pyridin-1-ylamine → HCID 59200069、化合物

HRID 2382018

反応式

HRID 2382018 の反応式
CC1C(C(O)=O)=CN=C([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=2)N=1.N1(N)C2C(=NC=CC=2)C=C1.[F:27][C:28]1[CH:29]=[C:30]2[C:34](=[CH:35][CH:36]=1)[N:33]([NH:37][C:38]([C:40]1[C:41]([CH3:52])=[N:42][C:43](C3C=CC=CN=3)=[N:44][CH:45]=1)=[O:39])[CH:32]=[CH:31]2>>[F:27][C:28]1[CH:29]=[C:30]2[C:34](=[CH:35][CH:36]=1)[N:33]([NH:37][C:38]([C:40]1[C:41]([CH3:52])=[N:42][C:43]([C:16]3[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=3)=[N:44][CH:45]=1)=[O:39])[CH:32]=[CH:31]2

参加物

4

反応物 3

HCID 19601545Pyrrolo[3,2-b]pyridin-1-ylamineHCID 591999524-Methyl-2-pyridin-2-yl-pyrimidine-5-carboxylic acid (5-fluoro-indol-1-yl)-amideHCID 617020254-Methyl-2-(pyridin-2-yl)pyrimidine-5-carboxylic acid

生成物 1

HCID 59200069HCID 59200069、化合物

実験手順

Following procedures similar to those of Example 127 but substituting 4-methyl-2-pyridin-3-yl-pyrimidine-5-carboxylic acid for 4-methyl-2-pyridin-2-yl-pyrimidine-5-carboxylic acid, and substituting 5-fluoro-indol-1-ylamine for pyrrolo[3,2-b]pyridine-1-ylamine, there is prepared 4-methyl-2-pyridin-2-yl-pyrimidine-5-carboxylic acid (5-fluoro-indol-1-yl)-amide (34%) as a solid. MS: 348 (M+H); 1H NMR (300 MHz, CD3OD): δ 2.85 (s, 3H), 6.57 (m, H), 7.02 (m, H), 7.23-7.46 (m, 2H), 7.62 (m, H), 8.70 (d, H), 8.91 (d, H), 9.17 (s, H), 9.63 (s, H).

出典と根拠

ORDレコード
ord-77a416d1fc9247239a0f9e2f3f6c9015
出典データセット
uspto-grants-2012_09
特許番号
US08258130B2

関連ノート

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