Pentane → 3-(Phenyl(4-(trifluoromethyl)phenyl)methyl)piperidine

HRID 2382187

反応式

HRID 2382187 の反応式
[C:1]1([C:7]([C:14]2[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][CH:15]=2)=[C:8]2[CH2:13][CH2:12][CH2:11][NH:10][CH2:9]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[H][H].CCCCC>CO.[Pd]>[C:1]1([CH:7]([C:14]2[CH:15]=[CH:16][C:17]([C:20]([F:23])([F:21])[F:22])=[CH:18][CH:19]=2)[CH:8]2[CH2:13][CH2:12][CH2:11][NH:10][CH2:9]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

6

反応物 3

HCID 8003PentaneHCID 687345843-(Phenyl(4-(trifluoromethyl)phenyl)methylene)piperidineHCID 178418361HCID 178418361、化合物

生成物 1

HCID 687345103-(Phenyl(4-(trifluoromethyl)phenyl)methyl)piperidine収率 99.4%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

To a solution of 3-(phenyl(4-(trifluoromethyl)phenyl)methylene)piperidine (1.0 g, 3.15 mmol) in methanol (25 mL) was charged with Pd/C under nitrogen atmosphere and fitted with hydrogen balloon using stopcock and covered with Teflon. The reaction mixture was stirred under hydrogen atmosphere for 8 h. It was filtered through celite, the celite was washed with methanol, and the solvent was removed under reduced pressure to afford the crude product which was then crashed out of pentane to give pure 3-(phenyl(4-(trifluoromethyl)phenyl)-methyl)piperidine (1.0 g, 98% yield) as a grey oil. MS (ESI, pos. ion) m/z: 320 (M+1).

後処理

  1. filtrationIt was filtered through celite
  2. washthe celite was washed with methanol
  3. customthe solvent was removed under reduced pressure
  4. customto afford the crude product which

出典と根拠

ORDレコード
ord-711f1e37505e41bda5207720d6ccd7d1
出典データセット
uspto-grants-2012_09
特許番号
US08258306B2

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