Hydroxyamine hydrochloride → 5-Bromo-2-chloro-N-[2-(N-formyl-N-hydroxy-amino)-ethyl]-benzamide
反応式
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([Cl:14])=[C:6]([CH:13]=1)[C:7]([NH:9][CH2:10][CH:11]=O)=[O:8].Cl.[NH2:16][OH:17].[C:18]([O-:21])(=O)C.[Na+]>CO>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([Cl:14])=[C:6]([CH:13]=1)[C:7]([NH:9][CH2:10][CH2:11][N:16]([CH:18]=[O:21])[OH:17])=[O:8]参加物
5
実験手順
To a solution of 5-bromo-2-chloro-N-(2-oxo-ethyl)-benzamide (11.8 g, 42.5 mmol) in MeOH (400 mL) was added hydroxylamine hydrochloride (5.9 g, 85 mmol) and sodium acetate (6.97 g, 85 mmol). The mixture was stirred 18 h and the MeOH was removed in vacuo. The residue was washed with water and was dried in vacuo for 18 h and used without further purification to provide the title compound (11.7 g, 94%) as a white solid. ESMS: M+H=291.
後処理
- customthe MeOH was removed in vacuo
- washThe residue was washed with water
- customwas dried in vacuo for 18 h
- customused without further purification
出典と根拠
- ORDレコード
- ord-3a55e9682d6b4d388a4708eee96a9a63
- 出典データセット
- uspto-grants-2005_02
- 特許番号
- US06852882B2
反応ノート
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