Pyridine → HCID 62909796、化合物

HRID 2382608ノート

反応式

HRID 2382608 の反応式
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([Cl:9])=[C:6]([CH:8]=1)[NH2:7].[C:10]1([S:16](Cl)(=[O:18])=[O:17])[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.N1C=CC=CC=1.CCOC(C)=O>C(Cl)Cl>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([Cl:9])=[C:6]([NH:7][S:16]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)(=[O:18])=[O:17])[CH:8]=1

参加物

6

反応物 4

HCID 1049PyridineHCID 7369Benzenesulfonyl chlorideHCID 8857Ethyl AcetateHCID 38307312-Chloro-5-bromoaniline

生成物 1

HCID 62909796HCID 62909796、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a stirring solution of 5-Bromo-2-chloroaniline (100 mg, 0.48 mmol) in DCM (5 ml) is added benzenesulfonyl chloride (280 mg, 202 ul, 1.58 mmol) and pyridine (195 ul, 2.42 mmol). The reaction mixture is stirred at room temperature for 18 hours. EtOAc (20 ml) is added and the reaction mixture is washed with 0.1 m HCl (20 ml), the phases are separated and the organic portion is washed with water (3×), dried over MgSO4, concentrated in vacuo and dried in a vacuum oven to afford the title compound.

後処理

  1. washthe reaction mixture is washed with 0.1 m HCl (20 ml)
  2. customthe phases are separated
  3. washthe organic portion is washed with water (3×)
  4. dry with materialdried over MgSO4
  5. concentrationconcentrated in vacuo
  6. customdried in a vacuum oven

出典と根拠

ORDレコード
ord-8ecb7044d6da4a6582e70e5b9ba65665
出典データセット
uspto-grants-2012_09
特許番号
US08263585B2

反応ノート

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