Sodium Hydroxide → HCID 58110193、化合物

HRID 238278

反応式

HRID 238278 の反応式
C[O:2][C:3]([C:5]1[CH:9]=[C:8]([C:10]2[CH:11]=[N:12][NH:13][CH:14]=2)[S:7][CH:6]=1)=[O:4].[OH-].[Na+]>CO>[NH:12]1[CH:11]=[C:10]([C:8]2[S:7][CH:6]=[C:5]([C:3]([OH:4])=[O:2])[CH:9]=2)[CH:14]=[N:13]1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 58110358methyl 5-(1H-pyrazol-4-yl)thiophene-3-carboxylate

生成物 1

HCID 58110193HCID 58110193、化合物収率 68.5%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

5-(1H-Pyrazol-4-yl)-thiophene-3-carboxylic acid methyl ester (2.8 g, 13.3 mmol) was dissolved in a mixture of methanol (18 mL) and a solution of aqueous sodium hydroxide (1 N, 18 mL) and the mixture stirred at 50° C. for 1.5 hours. The mixture was concentrated under vacuum and acidified with aqueous hydrochloric acid (1N). The resulting precipitate was isolated by filtration and washed with water before drying under vacuum to give the title compound as a white solid (1.77 g). LCMS m/z 195.1 [M+H]+. R.T.=3.23 min (Analytical Method 4). 1H NMR (400 MHz, d6-DMSO): δ 8.1 (s, 1H), 8.0 (m, 2H), 7.45 (s, 1H).

後処理

  1. concentrationThe mixture was concentrated under vacuum
  2. customThe resulting precipitate was isolated by filtration
  3. washwashed with water
  4. custombefore drying under vacuum

出典と根拠

ORDレコード
ord-f0015b981396470ca9ca90688886efa0
出典データセット
uspto-grants-2014_02
特許番号
US08642621B2

関連ノート

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