Acetyl chloride → HCID 68008288、化合物

HRID 238280ノート

反応式

HRID 238280 の反応式
Cl.[N+:2]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11]1[CH2:12][CH2:13][NH:14][CH2:15][CH:16]=1)([O-:4])=[O:3].[C:17](Cl)(=[O:19])[CH3:18]>N1C=CC=CC=1.C(Cl)Cl>[N+:2]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11]1[CH2:16][CH2:15][N:14]([C:17](=[O:19])[CH3:18])[CH2:13][CH:12]=1)([O-:4])=[O:3]

参加物

5

反応物 2

HCID 6367Acetyl chlorideHCID 67059989HCID 67059989、化合物

生成物 1

HCID 68008288HCID 68008288、化合物

試薬・触媒・溶媒 2

HCID 1049Pyridine溶媒HCID 6344Dichloromethane溶媒2 回

実験手順

4-(2-Nitro-phenyl)-1,2,3,6-tetrahydro-pyridine hydrochloride (0.44 g, 1.8 mmol) was dissolved in a solution of pyridine (0.4 mL) and DCM (20 mL). Acetyl chloride (0.142 mL) was added and the mixture was stirred for 0.5 hours. The mixture was diluted with DCM (20 mL) and the organic solution washed with water then 1 N hydrochloric acid. The solution was dried with magnesium sulphate, filtered and the solvent removed by evaporation under vacuum to give the title compound as an orange oil (0.4 g). LCMS m/z 247.4 [M+H]+. R.T.=3.70 min (Analytical Method 4).

後処理

  1. washthe organic solution washed with water
  2. dry with materialThe solution was dried with magnesium sulphate
  3. filtrationfiltered
  4. customthe solvent removed by evaporation under vacuum

出典と根拠

ORDレコード
ord-5af842cb979c44fd9d7473cd794a1b74
出典データセット
uspto-grants-2014_02
特許番号
US08642621B2

反応ノート

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