HCID 67059991、化合物 → 4-(2-Chlorophenyl)piperidine hydrochloride

HRID 238283ノート

反応式

HRID 238283 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]1[CH2:13][CH2:12][N:11](C(=O)C)[CH2:10][CH2:9]1>[OH-].[Na+].C(O)C>[ClH:1].[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]1[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]1

参加物

4

反応物 1

HCID 67059991HCID 67059991、化合物

生成物 1

HCID 219369514-(2-Chlorophenyl)piperidine hydrochloride収率 122.9%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 14798Sodium Hydroxide溶媒

反応条件

温度
50 °C

実験手順

1-[4-(2-Chloro-phenyl)-piperidin-1-yl]-ethanone (0.2 g) was dissolved in a solution of aqueous sodium hydroxide (1 N, 5 mL) and ethanol (10 mL) and heated to 50° C. for 6 hours. The solvent was removed by evaporation under vacuum, and the products extracted into ethyl acetate, washed with water (20 mL) then dried over magnesium sulphate, filtered and the solvent removed by evaporation under vacuum. The residue was dissolved in a solution of hydrogen chloride in dioxane (4 N, 1 mL) and the solvent evaported to give the title compound as a pale yellow solid (0.12 g). LCMS m/z 196.1 [M+H]+. R.T.=2.46 min (Analytical Method 4).

後処理

  1. customThe solvent was removed by evaporation under vacuum
  2. extractionthe products extracted into ethyl acetate
  3. washwashed with water (20 mL)
  4. dry with materialthen dried over magnesium sulphate
  5. filtrationfiltered
  6. customthe solvent removed by evaporation under vacuum
  7. dissolutionThe residue was dissolved in a solution of hydrogen chloride in dioxane (4 N, 1 mL)

出典と根拠

ORDレコード
ord-584ad0baa6964a0190a1c5a728750e8c
出典データセット
uspto-grants-2014_02
特許番号
US08642621B2

反応ノート

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