Water → 4-(Bromomethyl)-N-methylbenzenesulfonamide

HRID 2382933ノート

反応式

HRID 2382933 の反応式
[Br:1][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([S:9](Cl)(=[O:11])=[O:10])=[CH:5][CH:4]=1.Cl.[CH3:14][NH2:15].O>C(Cl)Cl>[Br:1][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([S:9]([NH:15][CH3:14])(=[O:11])=[O:10])=[CH:5][CH:4]=1

参加物

5

反応物 3

HCID 962WaterHCID 27344094-(Bromomethyl)benzenesulfonyl chlorideHCID 6364545Methylamine hydrochloride

生成物 1

HCID 100156454-(Bromomethyl)-N-methylbenzenesulfonamide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
0 °C

実験手順

To a chilled (0° C.) stirred solution of 4-(bromomethyl)-benzenesulfonylchloride (3.0 g, 11 mmol) in DCM (100 mL) was added methylamine hydrochloride (1.2 g, 12 mmol). After 30 minutes, water (100 mL) was added. The organic layer was separated, washed with brine (30 mL), and dried over sodium sulfate and concentrated in vauco to afford 4-bromomethyl-N-methyl-benzenesulfonamide.

後処理

  1. customThe organic layer was separated
  2. washwashed with brine (30 mL)
  3. dry with materialdried over sodium sulfate
  4. concentrationconcentrated in vauco

出典と根拠

ORDレコード
ord-4b9410be52a34c02a5e9b936ebade2bb
出典データセット
uspto-grants-2012_09
特許番号
US08263597B2

反応ノート

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