Dimethylformamide → 1-(4-fluoro-phenyl)-1H-indazole-4-carboxylic acid chloride

HRID 2382938ノート

反応式

HRID 2382938 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:16]3[CH:15]=[CH:14][CH:13]=[C:12]([C:17]([OH:19])=O)[C:11]=3[CH:10]=[N:9]2)=[CH:4][CH:3]=1.C(Cl)(=O)C([Cl:23])=O.CN(C=O)C>C(Cl)Cl>[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:16]3[CH:15]=[CH:14][CH:13]=[C:12]([C:17]([Cl:23])=[O:19])[C:11]=3[CH:10]=[N:9]2)=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 581387741-(4-fluoro-phenyl)-1H-indazole-4-carboxylic acid

生成物 1

HCID 581388741-(4-fluoro-phenyl)-1H-indazole-4-carboxylic acid chloride

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of 1-(4-fluoro-phenyl)-1H-indazole-4-carboxylic acid (0.400 g, 1.56 mmol) in CH2Cl2 (5 mL) at room temperature was added oxalyl chloride (0.86 mL, 1.7 mmol) followed by DMF (20 μL). Gas evolution was observed. After 30 minutes, the solution was concentrated in vacuo to afford 1-(4-fluoro-phenyl)-1H-indazole-4-carboxylic acid chloride which was used without further purification.

後処理

  1. concentrationthe solution was concentrated in vacuo

出典と根拠

ORDレコード
ord-6c8abf9b1eaa4ef1bdae335d11c32f71
出典データセット
uspto-grants-2012_09
特許番号
US08263597B2

反応ノート

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