4-(5H-pyrrolo[1,2-c]imidazol-7-yl)benzonitrile → HCID 16749887、化合物

HRID 2383240

反応式

HRID 2383240 の反応式
[CH:1]1[N:5]=[CH:4][N:3]2[CH2:6][CH:7]=[C:8]([C:9]3[CH:16]=[CH:15][C:12]([C:13]#[N:14])=[CH:11][CH:10]=3)[C:2]=12>CO.[Pd]>[CH:1]1[N:5]=[CH:4][N:3]2[CH2:6][CH2:7][CH:8]([C:9]3[CH:16]=[CH:15][C:12]([C:13]#[N:14])=[CH:11][CH:10]=3)[C:2]=12

参加物

4

反応物 1

HCID 669338694-(5H-pyrrolo[1,2-c]imidazol-7-yl)benzonitrile

生成物 1

HCID 16749887HCID 16749887、化合物

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A solution of 0.99 mmol of 4-(5H-pyrrolo[1,2-c]imidazol-7-yl)benzonitrile in 15 ml of MeOH is hydrogenated in the presence of 123 mg of 10% Pd/C at room temperature for 5.5 hours. The reaction mixture is subjected to clarifying filtration and the filtrate is evaporated. From the residue the title compound is obtained by means of flash chromatography (SiO2 60 F) as a pale reddish solid. Rf=0.22 (dichloromethane/ammonia (2M in EtOH) 97:3), Rt=4.43 (Gradient I).

後処理

  1. filtrationfiltration
  2. customthe filtrate is evaporated

出典と根拠

ORDレコード
ord-4f18c979079f485fade6fa886b5989ed
出典データセット
uspto-grants-2012_09
特許番号
US08263615B2

関連ノート

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