Toluene → HCID 178419490、化合物

HRID 2383426ノート

反応式

HRID 2383426 の反応式
[Br:1][C:2]1[C:14]2[C:13]3[CH2:12][CH2:11][N:10](C(OC(C)(C)C)=O)[CH2:9][C:8]=3[CH:7]=[N:6][C:5]=2[NH:4][N:3]=1.[F:22][C:23]([F:28])([F:27])[C:24]([OH:26])=[O:25].C1(C)C=CC=CC=1>O1CCOCC1>[F:22][C:23]([F:28])([F:27])[C:24]([O-:26])=[O:25].[Br:1][C:2]1[C:14]2[C:13]3[CH2:12][CH2:11][NH2+:10][CH2:9][C:8]=3[CH:7]=[N:6][C:5]=2[NH:4][N:3]=1

参加物

5

反応物 3

HCID 1140TolueneHCID 6422Trifluoroacetic acidHCID 178451611HCID 178451611、化合物

生成物 1

HCID 178419490HCID 178419490、化合物

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

To tert-butyl 1-bromo-8,9-dihydro-3H-pyrazolo[3,4-c][2,7]naphthyridine-7(6H)-carboxylate (0.23 g, 0.43 mmol) was added trifluoroacetic acid (2 mL). The reaction mixture was stirred at room temperature for 30 minutes. On completion of the reaction, toluene (3 mL) and 1,4-dioxane (2 mL) were added and the solvents removed under reduced pressure. The crude product, 1-bromo-6,7,8,9-tetrahydro-3H-pyrazolo[3,4-c][2,7]naphthyridin-7-ium 2,2,2-trifluoroacetate was obtained as brown foam and was used in the next step without any further purification. LCMS [M+H]: 253.

後処理

  1. additionwere added
  2. customthe solvents removed under reduced pressure

出典と根拠

ORDレコード
ord-8f5cb8fa8ca84106a09a80ddd7f0c789
出典データセット
uspto-grants-2012_09
特許番号
US08263610B2

反応ノート

読み込み中…