Guanidine Hydrochloride → 2-Amino-6-(4-methoxydibenzo[b,d]furan-1-yl)-4-oxo-3,4,5,6,7,8-hexahydroquinazoline-6-carbonitrile

HRID 2383983

反応式

HRID 2383983 の反応式
C[O:2][C:3]([CH:5]1[CH2:10][C:9]([C:26]#[N:27])([C:11]2[C:19]3[C:18]4[CH:20]=[CH:21][CH:22]=[CH:23][C:17]=4[O:16][C:15]=3[C:14]([O:24][CH3:25])=[CH:13][CH:12]=2)[CH2:8][CH2:7][C:6]1=O)=O.Cl.[NH2:30][C:31]([NH2:33])=[NH:32].C[O-].[Na+]>CO>[NH2:32][C:31]1[NH:33][C:3](=[O:2])[C:5]2[CH2:10][C:9]([C:11]3[C:19]4[C:18]5[CH:20]=[CH:21][CH:22]=[CH:23][C:17]=5[O:16][C:15]=4[C:14]([O:24][CH3:25])=[CH:13][CH:12]=3)([C:26]#[N:27])[CH2:8][CH2:7][C:6]=2[N:30]=1

参加物

5

反応物 3

HCID 5742Guanidine HydrochlorideHCID 10942334Sodium MethoxideHCID 247555955-Cyano-5-(4-methoxy-dibenzofuran-1-yl)-2-oxo-cyclohexane carboxylic acid methyl ester

生成物 1

HCID 1356204902-Amino-6-(4-methoxydibenzo[b,d]furan-1-yl)-4-oxo-3,4,5,6,7,8-hexahydroquinazoline-6-carbonitrile

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A mixture of the compound obtained in example 1 (200 mg, 0.53 mmol), guanidine HCl (127 mg, 1.326 mmol) and sodium methoxide (100 mg) in 2 ml methanol was stirred overnight at room temperature. The solvent was evaporated under vacuum and the crude residue was purified by column chromatography to get 150 mg (73.3% yields) as a white solid product. MP-decomposes at 300° C.

後処理

  1. customThe solvent was evaporated under vacuum
  2. customthe crude residue was purified by column chromatography
  3. customto get
  4. custom150 mg (73.3% yields) as a white solid product
  5. customat 300° C.

出典と根拠

ORDレコード
ord-5118ad178b0a4837bf9e7e93f162879a
出典データセット
uspto-grants-2012_09
特許番号
US08263648B2

関連ノート

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