Guanidine Hydrochloride → 2-Amino-6-(4-methoxydibenzo[b,d]furan-1-yl)-5,6,7,8-tetrahydroquinazoline-6-carbonitrile

HRID 2383984ノート

反応式

HRID 2383984 の反応式
CN(/[CH:4]=[C:5]1\[CH2:6][C:7]([C:14]2[C:22]3[C:21]4[CH:23]=[CH:24][CH:25]=[CH:26][C:20]=4[O:19][C:18]=3[C:17]([O:27][CH3:28])=[CH:16][CH:15]=2)([C:12]#[N:13])[CH2:8][CH2:9][C:10]\1=O)C.Cl.[NH2:30][C:31]([NH2:33])=[NH:32].[O-]CC.[Na+]>C(O)C>[NH2:32][C:31]1[N:33]=[CH:4][C:5]2[CH2:6][C:7]([C:14]3[C:22]4[C:21]5[CH:23]=[CH:24][CH:25]=[CH:26][C:20]=5[O:19][C:18]=4[C:17]([O:27][CH3:28])=[CH:16][CH:15]=3)([C:12]#[N:13])[CH2:8][CH2:9][C:10]=2[N:30]=1

参加物

5

反応物 3

HCID 5742Guanidine HydrochlorideHCID 2723922Sodium ethoxideHCID 24804131(3E)-3-[(Dimethylamino)methylene]-1-(4-methoxydibenzo[b,d]furan-1-yl)-4-oxocyclohexanecarbonitrile

生成物 1

HCID 248044552-Amino-6-(4-methoxydibenzo[b,d]furan-1-yl)-5,6,7,8-tetrahydroquinazoline-6-carbonitrile

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
75 °C

実験手順

A mixture of the compound obtained in example 6 (100 mg, 0.267 mmol), guanidine HCl (33.5 mg, 0.35 mmol) and sodium ethoxide (25 mg, 0.35 mmol) in 5 ml ethanol was heated at 70-80° C. for 1 hr. The mixture was cooled to room temperature and the solvent was evaporated under vacuum. The crude residue was purified by column chromatography to get 80 mg (81% yields) of a white colored solid product.

後処理

  1. temperatureThe mixture was cooled to room temperature
  2. customthe solvent was evaporated under vacuum
  3. customThe crude residue was purified by column chromatography
  4. customto get
  5. custom80 mg (81% yields) of a white colored solid product

出典と根拠

ORDレコード
ord-4feef8dbcf2e402496b1c72606782ae9
出典データセット
uspto-grants-2012_09
特許番号
US08263648B2

反応ノート

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