Hydrochloric Acid → HCID 53904370、化合物

HRID 2384068ノート

反応式

HRID 2384068 の反応式
C([O:3][C:4](=[O:13])[CH2:5][C:6]1[S:7][C:8]([CH2:11][CH3:12])=[N:9][N:10]=1)C.[OH-].[Na+].Cl>C(O)C>[CH2:11]([C:8]1[S:7][C:6]([CH2:5][C:4]([OH:13])=[O:3])=[N:10][N:9]=1)[CH3:12]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 67505705(5-Ethyl-[1,3,4]thiadiazol-2-yl)-acetic acid ethyl ester

生成物 1

HCID 53904370HCID 53904370、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Next, to a solution of (5-ethyl-[1,3,4]thiadiazol-2-yl)-acetic acid ethyl ester (230 mg, 1.15 mmol) in ethanol (5 mL) is added aqueous 1M NaOH (2 mL, 2.0 mmol) and the mixture is stirred at room temperature for 18 hours. The mixture is acidified with aqueous 1M HCl and the ethanol is removed under reduced pressure. The remaining aqueous solution is lyophilized to give (5-ethyl-[1,3,4]thiadiazol-2-yl)-acetic acid.

後処理

  1. customthe ethanol is removed under reduced pressure

出典と根拠

ORDレコード
ord-4d612c813040417f91833d76880ca0f6
出典データセット
uspto-grants-2012_09
特許番号
US08263629B2

反応ノート

読み込み中…