Nitroindoline → 2,3-dihydro-1H-indol-1-amine

HRID 238415ノート

反応式

HRID 238415 の反応式
[N+:1]([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH2:6][CH2:5]1)([O-])=O>[Pd]>[NH2:1][N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH2:6][CH2:5]1

参加物

3

反応物 1

HCID 21959507Nitroindoline

生成物 1

HCID 27609322,3-dihydro-1H-indol-1-amine

試薬・触媒・溶媒 1

HCID 23938Palladium触媒

実験手順

Substituted indolines are prepared such as by the procedures described in Scheme 21. Substituted amino-indolines 64 are prepared from the nitroindoline 62 and a ketone in the presence of NaHB(OAc)3 to form the 1-substituted indoline 63. The nitroindoline 63 is hydrogenated, such as with H2 in the presence of a catalyst, such as Pd/C, to yield the amino-indoline 64.

出典と根拠

ORDレコード
ord-a2d22edcec944c5bbc04cf379c179a9e
出典データセット
uspto-grants-2014_02
特許番号
US08642624B2

反応ノート

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