Nitroindoline → 2,3-dihydro-1H-indol-1-amine

HRID 238416ノート

反応式

HRID 238416 の反応式
[N+:1]([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH2:6][CH2:5]1)([O-])=O>[Pd]>[NH2:1][N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH2:6][CH2:5]1

参加物

3

反応物 1

HCID 21959507Nitroindoline

生成物 1

HCID 27609322,3-dihydro-1H-indol-1-amine

試薬・触媒・溶媒 1

HCID 23938Palladium触媒

実験手順

Alternatively, substituted amino-indolines 67 are prepared from the nitroindoline 62. Nitroindoline 62, is reacted with an acid chloride to form an amide. Further treatment with a primary or secondary amine, preferably a secondary amine, such as in the presence of NaI, at a temperature above about 50° C., and preferably at about 70° C. yields the nitroindoline 65. The nitro compound 65 is hydrogenated, such as with H2 in the presence of a catalyst, such as Pd/C, to yield the amino-indoline 66. The carbonyl is reduced, such as with BH3-THF yields 1-aminoalkyl-indolines 67.

出典と根拠

ORDレコード
ord-54e50ead3fc4452d9ce41fc3c76d90cb
出典データセット
uspto-grants-2014_02
特許番号
US08642624B2

反応ノート

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