Hexane → 5-Bromo-4-tert-butyl-1,3-thiazol-2-amine

HRID 2384470ノート

反応式

HRID 2384470 の反応式
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7]([CH3:10])([CH3:9])[CH3:8])[N:6]=1.[Br:11]N1C(=O)CCC1=O.CCCCCC>C(Cl)(Cl)(Cl)Cl>[NH2:1][C:2]1[S:3][C:4]([Br:11])=[C:5]([C:7]([CH3:10])([CH3:9])[CH3:8])[N:6]=1

参加物

5

反応物 3

HCID 8058HexaneHCID 67184N-bromobutanimideHCID 27342024-tert-Butyl-1,3-thiazol-2-amine

生成物 1

HCID 7291355-Bromo-4-tert-butyl-1,3-thiazol-2-amine収率 93.7%

試薬・触媒・溶媒 1

HCID 5943Carbon Tetrachloride溶媒

実験手順

2-Amino-4-[(1,1-dimethyl)ethyl]thiazole (0.87 g, 5.6 mmol) was dissolved in carbon tetrachloride (9 mL). N-Bromosuccinimide (1.00 g, 5.6 mmol) was added, and the mixture was stirred at room temperature for 1 hour. Hexane was added to the reaction mixture, the insoluble matter was filtered off, and the residue obtained by evaporation of the filtrate under reduced pressure was purified by chromatography on silica gel (hexane:ethyl acetate=2:1) to give the title compound (1.23 g, 93.7%) as a yellowish gray powder.

後処理

  1. filtrationthe insoluble matter was filtered off
  2. customthe residue obtained by evaporation of the filtrate under reduced pressure
  3. customwas purified by chromatography on silica gel (hexane:ethyl acetate=2:1)

出典と根拠

ORDレコード
ord-1c8e0055749d486a96b5d9abd4fbb6f4
出典データセット
uspto-grants-2012_09
特許番号
US08263657B2

反応ノート

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