Acetic Acid → Methyl 2-(4-aminophenyl)-2-methylpropanoate
反応式
[CH3:1][O:2][C:3](=[O:16])[C:4]([CH3:15])([C:6]1[CH:11]=[CH:10][C:9]([N+:12]([O-])=O)=[CH:8][CH:7]=1)[CH3:5].C(O)(=O)C>C1COCC1.[Zn]>[CH3:1][O:2][C:3](=[O:16])[C:4]([C:6]1[CH:7]=[CH:8][C:9]([NH2:12])=[CH:10][CH:11]=1)([CH3:15])[CH3:5]参加物
5
実験手順
2-Methyl-2-(4-nitro-phenyl)-propionic acid methyl ester (2.1 g) was dissolved in THF (70 ml) and acetic acid (5 ml) and Zn (10 g) were added. The mixture was stirred for 1 h and filtered through Celite®. The filtrate was rinsed with EtOAc and the organics were evaporated to a residue which was purified on silica gel chromatography (40% EtOAc/hexanes) to provide the desired compound as a yellow oil. M+H 194.
後処理
- filtrationfiltered through Celite®
- washThe filtrate was rinsed with EtOAc
- customthe organics were evaporated to a residue which
- customwas purified on silica gel chromatography (40% EtOAc/hexanes)
出典と根拠
- ORDレコード
- ord-9dc098c7d92c49b2b058d0ad6a4dc885
- 出典データセット
- uspto-grants-2014_02
- 特許番号
- US08642624B2
反応ノート
読み込み中…