Ammonium Chloride → Tert-butyl 4-aminophenethylcarbamate

HRID 238494

反応式

HRID 238494 の反応式
[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][C:14]([N+:17]([O-])=O)=[CH:13][CH:12]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[NH4+].[Cl-]>CCO.O.[Fe]>[NH2:17][C:14]1[CH:13]=[CH:12][C:11]([CH2:10][CH2:9][NH:8][C:6]([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[O:7])=[CH:16][CH:15]=1

参加物

6

反応物 2

HCID 25517Ammonium ChlorideHCID 10264884Tert-butyl N-[2-(4-nitrophenyl)ethyl]carbamate

生成物 1

HCID 382207Tert-butyl 4-aminophenethylcarbamate

試薬・触媒・溶媒 3

HCID 23925Iron触媒HCID 702Ethanol溶媒HCID 962Water溶媒

反応条件

温度
80 °C

実験手順

A mixture of (tert-butoxy)-N-[2-(4-nitrophenyl)ethyl]-carboxamide (570 mg, 2.15 mmol, Step A), iron powder (602 mg, 10.75 mmol) and NH4Cl (82 mg, 1.5 mmol) in EtOH (6 mL) and H2O (6 ml) was stirred for 4 h at 80° C. Filtration and concentration gave the crude compound, which was used in next step without further purification.

後処理

  1. filtrationFiltration and concentration

出典と根拠

ORDレコード
ord-427175b1319e4c6cb54912b600fac544
出典データセット
uspto-grants-2014_02
特許番号
US08642624B2

関連ノート

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