1-Methyl-4-(4-nitrophenyl)piperazine → 4-(4-Methylpiperazin-1-yl)aniline

HRID 238502ノート

反応式

HRID 238502 の反応式
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]2[CH:13]=[CH:12][C:11]([N+:14]([O-])=O)=[CH:10][CH:9]=2)[CH2:4][CH2:3]1>[Pd].CCO.CO>[CH3:1][N:2]1[CH2:3][CH2:4][N:5]([C:8]2[CH:13]=[CH:12][C:11]([NH2:14])=[CH:10][CH:9]=2)[CH2:6][CH2:7]1

参加物

4

反応物 1

HCID 28251981-Methyl-4-(4-nitrophenyl)piperazine

生成物 1

HCID 7372534-(4-Methylpiperazin-1-yl)aniline

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 18681192Ethanol, mixt. with methanol溶媒

実験手順

4-Methyl-1-(4-nitrophenyl)piperazine (2.0 g, 9 mmol, Step A) and 10% Pd/C (200 mg) were added to EtOH/MeOH (1:1) (50 ml) at RT. The reaction stirred under a H2 atmosphere (via balloon) overnight. The mixture was filtered through a plug of Celite® and the filtrate was concentrated under reduced pressure to leave the desired material as a light yellow oil. The material was used in subsequent reaction without purification. MS: (ES+) 192 (M+1)+; (ES−): 190 (M−1)−. Calc'd for C11H17N3: 191.14.

後処理

  1. filtrationThe mixture was filtered through a plug of Celite®
  2. concentrationthe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-fba555902b8b42b196b2c77b87122dd3
出典データセット
uspto-grants-2014_02
特許番号
US08642624B2

反応ノート

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