1,2-Dichloroethane → (R)-N'-(2-(3-chloro-4-cyano-2-methylphenylamino)-3-hydroxy-3-methylbutanoyl)-4-cyanobenzohydrazide

HRID 238570

反応式

HRID 238570 の反応式
[Cl:1][C:2]1[C:3]([CH3:19])=[C:4]([NH:10][C@H:11]([C:15]([OH:18])([CH3:17])[CH3:16])[C:12]([OH:14])=O)[CH:5]=[CH:6][C:7]=1[C:8]#[N:9].[C:20]([C:22]1[CH:31]=[CH:30][C:25]([C:26]([NH:28][NH2:29])=[O:27])=[CH:24][CH:23]=1)#[N:21].C1C=CC2N(O)N=NC=2C=1.C(Cl)CCl.CCN(CC)CC>C1COCC1>[Cl:1][C:2]1[C:3]([CH3:19])=[C:4]([NH:10][C@H:11]([C:15]([OH:18])([CH3:17])[CH3:16])[C:12]([NH:29][NH:28][C:26](=[O:27])[C:25]2[CH:24]=[CH:23][C:22]([C:20]#[N:21])=[CH:31][CH:30]=2)=[O:14])[CH:5]=[CH:6][C:7]=1[C:8]#[N:9]

参加物

7

反応物 5

HCID 111,2-DichloroethaneHCID 8471TriethylamineHCID 757711-HydroxybenzotriazoleHCID 4567324-CyanobenzohydrazideHCID 66625199(R)-2-(3-chloro-4-cyano-2-methylphenylamino)-3-hydroxy-3-methylbutanoic acid

生成物 1

HCID 66625521(R)-N'-(2-(3-chloro-4-cyano-2-methylphenylamino)-3-hydroxy-3-methylbutanoyl)-4-cyanobenzohydrazide収率 65.7%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
-20 °C

実験手順

To a solution of (R)-2-(3-chloro-4-cyano-2-methylphenylamino)-3-hydroxy-3-methylbutanoic acid (3.5 g, 12.4 mmol) in THF (80 mL) were added 4-cyanobenzhydrazide (2.3 g, 14.3 mmol), HOBt (1.70 g, 12.6 mmol), EDC (3.56 g, 18.6 mmol) and Et3N (2.8 mL, 20.1 mmol) at −20° C. sequentially. After addition, the mixture was stirred at −20° C. for 30 min., then room temperature overnight. The reaction was quenched by adding ice-water. After removal of the THF, the residue was extracted with EtOAc (300 mL). The EtOAc extracts were washed with water, brine and dried over Na2SO4. The filtrate was concentrated and purified by flash chromatography to give the title compound (R)—N′-(2-(3-chloro-4-cyano-2-methylphenylamino)-3-hydroxy-3-methylbutanoyl)-4-cyanobenzohydrazide (3.47 g, 65%). 1H NMR (400 MHz, Acetone-d6, δ in ppm) 9.72 (b, 2H), 8.08 (d, J=8.4 Hz, 2H), 7.92 (d, J=8.4 Hz, 2H), 7.52 (d, J=8.6 Hz, 1H), 6.72 (d, J=8.6 Hz, 1H), 5.55 (d, J=7.2 Hz, 1H), 4.08 (d, J=7.2 Hz, 1H), 2.35 (s, 3H), 1.47 (s, 3H), 1.42 (s, 3H).

後処理

  1. additionAfter addition
  2. customroom temperature overnight
  3. customThe reaction was quenched
  4. additionby adding ice-water
  5. customAfter removal of the THF
  6. extractionthe residue was extracted with EtOAc (300 mL)
  7. washThe EtOAc extracts were washed with water, brine
  8. dry with materialdried over Na2SO4
  9. concentrationThe filtrate was concentrated
  10. custompurified by flash chromatography

出典と根拠

ORDレコード
ord-86367227076242a39b5bbc5bd89f5b50
出典データセット
uspto-grants-2014_02
特許番号
US08642632B2

関連ノート

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