Triethylamine → 1-(3-Bromo-4-methylphenyl)-3-(3,5-dichlorophenyl)-4,4,4-trifluoro-3-hydroxybutane-1-one

To a solution of 3.42 g of 3′,5′-dichloro-2,2,2-trifluoroacetophenone and 3.00 g of 3′-bromo-4′-methylacetophenone in 5 mL of heptane, 0.71 g of triethylamine was added and the resultant reaction mixture was stirred at 60° C. for 8 hours. After the completion of the reaction, the reaction mixture was left to be cooled down to room temperature. A deposited solid was separated off and was washed with 3 mL of hexane to obtain 6.16 g of the objective substance as a white crystal.

1. customthe resultant reaction mixture
2. customAfter the completion of the reaction
3. waitthe reaction mixture was left
4. temperatureto be cooled down to room temperature
5. customA deposited solid was separated off
6. washwas washed with 3 mL of hexane
7. customto obtain 6.16 g of the objective substance as a white crystal

ORDレコード

ord-4689ada0b0eb4ff2898deb9c6370d6ec

出典データセット

uspto-grants-2012_09

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US08268754B2