Chlorosulfonic acid → 5-(2-Acetamido-4-methylthiazol-5-yl)furan-2-sulfonyl chloride
反応式
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[S:10][C:9]([NH:11][C:12](=[O:14])[CH3:13])=[N:8][C:7]=1[CH3:15].[S:16]([Cl:20])(=O)(=[O:18])[OH:17]>>[C:12]([NH:11][C:9]1[S:10][C:6]([C:2]2[O:1][C:5]([S:16]([Cl:20])(=[O:18])=[O:17])=[CH:4][CH:3]=2)=[C:7]([CH3:15])[N:8]=1)(=[O:14])[CH3:13]参加物
3
実験手順
To N-(5-(furan-2-yl)-4-methylthiazol-2-yl)acetamide (0.443 g) under an ice-salt bath was added sulfurochloridoic acid (ClSO3H, 5 ml). After 30 min, the reaction was poured into crushed ice (150 g). Extraction with dichloromethane (3×30 ml), drying and concentration gave 5-(2-acetamido-4-methylthiazol-5-yl)furan-2-sulfonyl chloride (0.359 g) that was used directly for next step.
後処理
- additionthe reaction was poured
- extractionExtraction with dichloromethane (3×30 ml)
- customdrying
- concentrationconcentration
出典と根拠
- ORDレコード
- ord-0c5e5284cfa54de9a260e7292472f86f
- 出典データセット
- uspto-grants-2012_09
- 特許番号
- US08268818B2
反応ノート
読み込み中…