2-(3-Fluoro-4-methoxyphenyl)ethanamine → 4-(2-Aminoethyl)-2-fluorophenol

HRID 2386462ノート

反応式

HRID 2386462 の反応式
[F:1][C:2]1[CH:3]=[C:4]([CH2:10][CH2:11][NH2:12])[CH:5]=[CH:6][C:7]=1[O:8]C>Br>[NH2:12][CH2:11][CH2:10][C:4]1[CH:5]=[CH:6][C:7]([OH:8])=[C:2]([F:1])[CH:3]=1

参加物

3

反応物 1

HCID 4263002-(3-Fluoro-4-methoxyphenyl)ethanamine

生成物 1

HCID 1932924-(2-Aminoethyl)-2-fluorophenol

試薬・触媒・溶媒 1

HCID 260Hydrogen Bromide溶媒

実験手順

Intermediate 82 was dissolved in 200 mL of 48% aqueous HBr and the mixture heated to reflux for 2 hours. The Solvent was removed by rotary evaporation. The residue was taken up in 100 mL of ethanol and the solvent again removed. This was repeated twice more to remove residual water. LC-MS showed the product was >90% pure had the expected M+H+ of 156.

後処理

  1. temperaturethe mixture heated
  2. temperatureto reflux for 2 hours
  3. customThe Solvent was removed by rotary evaporation
  4. customthe solvent again removed
  5. customto remove residual water

出典と根拠

ORDレコード
ord-4035c7512b6c4308a9a4a02c4ef4de14
出典データセット
uspto-grants-2012_09
特許番号
US08268822B2

反応ノート

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