(4-Acetoxy-3-ethynyl-6-fluoro-naphthalen-2-yl)-acetic acid methyl ester → (4-Acetoxy-3-ethyl-6-fluoro-naphthalen-2-yl)acetic acid methyl ester

HRID 238647ノート

反応式

HRID 238647 の反応式
[CH3:1][O:2][C:3](=[O:22])[CH2:4][C:5]1[C:14]([C:15]#[CH:16])=[C:13]([O:17][C:18](=[O:20])[CH3:19])[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([F:21])[CH:11]=2)[CH:6]=1.[H][H]>CO.[Pd]>[CH3:1][O:2][C:3](=[O:22])[CH2:4][C:5]1[C:14]([CH2:15][CH3:16])=[C:13]([O:17][C:18](=[O:20])[CH3:19])[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([F:21])[CH:11]=2)[CH:6]=1

参加物

5

反応物 2

HCID 59326564(4-Acetoxy-3-ethynyl-6-fluoro-naphthalen-2-yl)-acetic acid methyl esterHCID 178418361HCID 178418361、化合物

生成物 1

HCID 59326550(4-Acetoxy-3-ethyl-6-fluoro-naphthalen-2-yl)acetic acid methyl ester収率 98.7%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

To a solution of (4-acetoxy-3-ethynyl-6-fluoro-naphthalen-2-yl)-acetic acid methyl ester (50 mg) in methanol was added 10% palladium on carbon (10 mg). The resulting mixture was hydrogenated under 40 psi of hydrogen for 2 hours and filtered. The filtrate was concentrated in vacuo to afford (4-acetoxy-3-ethyl-6-fluoro-naphthalen-2-yl)acetic acid methyl ester (50 mg) as a colorless oil.

後処理

  1. filtrationfiltered
  2. concentrationThe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-96baf2beaa0b411dad6a853321e885c7
出典データセット
uspto-grants-2014_02
特許番号
US08642629B2

反応ノート

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