Methanol → Methyl 2-chloro-5-(trifluoromethyl)pyridine-4-carboxylate
反応式
[C:1](Cl)(=O)C(Cl)=O.[Cl:7][C:8]1[CH:9]=[C:10]([C:14]([C:17]([F:20])([F:19])[F:18])=[CH:15][N:16]=1)[C:11]([OH:13])=[O:12].CO>C(Cl)Cl.CN(C=O)C>[CH3:1][O:12][C:11](=[O:13])[C:10]1[C:14]([C:17]([F:20])([F:18])[F:19])=[CH:15][N:16]=[C:8]([Cl:7])[CH:9]=1参加物
6
実験手順
Oxalyl chloride (0.5 ml) was added to a solution of 2-chloro-5-(trifluoromethyl)isonicotinic acid (CAS Reg. No. 505084-58-2, 68 mg) in DCM (5 ml). DMF (1 drop) was added and the resulting mixture was stirred overnight at room temperature. Methanol (5 ml) was added and the mixture was concentrated to dryness. The crude product was used in the next step without further purification.
後処理
- concentrationthe mixture was concentrated to dryness
- customThe crude product was used in the next step without further purification
出典と根拠
- ORDレコード
- ord-392ec75cd9614ab18dd961e4217e665d
- 出典データセット
- uspto-grants-2012_09
- 特許番号
- US08268820B2
反応ノート
読み込み中…