Hydrogen Bromide → 3'-Amino-2'-hydroxy-biphenyl-3-carboxylic acid hydrobromide

HRID 238697ノート

反応式

HRID 238697 の反応式
C[O:2][C:3]1[C:8]([NH2:9])=[CH:7][CH:6]=[CH:5][C:4]=1[C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([C:16]([OH:18])=[O:17])[CH:11]=1.[BrH:19]>>[BrH:19].[NH2:9][C:8]1[C:3]([OH:2])=[C:4]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([C:16]([OH:18])=[O:17])[CH:11]=2)[CH:5]=[CH:6][CH:7]=1

参加物

3

反応物 2

HCID 260Hydrogen BromideHCID 574837863'-Amino-2'-methoxy-[1,1'-biphenyl]-3-carboxylic acid

生成物 1

HCID 574837893'-Amino-2'-hydroxy-biphenyl-3-carboxylic acid hydrobromide収率 88.8%

反応条件

温度
120 °C

実験手順

Employing a known method outlined in patent application WO0189457: 2′-Methoxy-3′-amino-biphenyl-3-carboxylic acid 1e (2.5 g, 10.3 mmol) was dissolved in 100 mL of hydrobromic acid (40%). The reaction mixture was heated to reflux at 120° C. overnight. The mixture was concentrated under reduced pressure and the resulting residue was purified by silica gel column chromatography to obtain the title compound 3′-amino-2′-hydroxy-biphenyl-3-carboxylic acid hydrobromide 1f (2.4 g, 88.8%) as a khaki solid.

後処理

  1. temperatureThe reaction mixture was heated
  2. concentrationThe mixture was concentrated under reduced pressure
  3. customthe resulting residue was purified by silica gel column chromatography

出典と根拠

ORDレコード
ord-736d7ace2e9e4f18bc98395e403e2e73
出典データセット
uspto-grants-2014_02
特許番号
US08642637B2

反応ノート

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