tert-Butyl 3-cyanomorpholine-4-carboxylate → 3-Aminomethyl-4-boc-morpholine
反応式
[C:1]([CH:3]1[CH2:8][O:7][CH2:6][CH2:5][N:4]1[C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])#[N:2]>CO.O=[Pt]=O>[NH2:2][CH2:1][CH:3]1[CH2:8][O:7][CH2:6][CH2:5][N:4]1[C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10]参加物
4
実験手順
To a solution (0.3 M) of tert-butyl 3-cyano-4-morpholinecarboxylate (prepared as described in the J. Med. Chem. 2007, 50, 4953-4975) in MeOH was added PtO2 (0.1 eq) and the mixture was stirred O/N under an H2 atmosphere at 50 psi. The reaction mixture was filtered and concentrated under reduced pressure to afford the title compound RR1. MS (ES) C10H20N2O3 required: 216, found: 217 (M+H)+.
後処理
- filtrationThe reaction mixture was filtered
- concentrationconcentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-fd008a8468e14f18a320d4456b692c1c
- 出典データセット
- uspto-grants-2012_09
- 特許番号
- US08268827B2
反応ノート
読み込み中…