Sodium borohydride → (2-Amino-4-methyl-6-(pentylamino)pyrimidin-5-yl)methanol
反応式
[NH2:1][C:2]1[N:7]=[C:6]([CH3:8])[C:5]([CH:9]=[O:10])=[C:4]([NH:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16])[N:3]=1.[BH4-].[Na+]>CO>[NH2:1][C:2]1[N:7]=[C:6]([CH3:8])[C:5]([CH2:9][OH:10])=[C:4]([NH:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16])[N:3]=1参加物
4
実験手順
To the product from step (ii) (4 g) in MeOH (50 ml), sodium borohydride (0.7 g) was added portionwise over 5 min. The mixture was stirred at rt for 1 h then the solvent removed under reduced pressure. The residue was partitioned between EtOAc and water, the organics were separated, dried and evaporated under reduced pressure to give the subtitle compound, 3.89 g.
後処理
- customthe solvent removed under reduced pressure
- customThe residue was partitioned between EtOAc and water
- customthe organics were separated
- customdried
- customevaporated under reduced pressure
出典と根拠
- ORDレコード
- ord-547146c5f8b049e9aa0a1eff84f3b9a2
- 出典データセット
- uspto-grants-2012_09
- 特許番号
- US08268990B2
反応ノート
読み込み中…