Trifluoroacetic acid → HCID 57916235、化合物

HRID 2388662ノート

反応式

HRID 2388662 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH3:8])[C:3]=1[S:9]([N:12]([CH2:16][CH2:17][O:18][CH2:19][C:20]([O:22]C(C)(C)C)=[O:21])[CH:13]1[CH2:15][CH2:14]1)(=[O:11])=[O:10].FC(F)(F)C(O)=O>ClCCl>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH3:8])[C:3]=1[S:9]([N:12]([CH2:16][CH2:17][O:18][CH2:19][C:20]([OH:22])=[O:21])[CH:13]1[CH2:14][CH2:15]1)(=[O:10])=[O:11]

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 57916276tert-butyl 2-(2-(2-chloro-N-cyclopropyl-6-methylphenylsulfonamido)ethoxy)acetate

生成物 1

HCID 57916235HCID 57916235、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a dichloromethane (10 ml/mmol) solution of tert-butyl 2-(2-(2-chloro-N-cyclopropyl-6-methylphenylsulfonamido)ethoxy)acetate (1 eq.) was added trifluoroacetic acid (13 eq.) at 0° C. and the resulting reaction mixture was stirred at ambient temperature for 2 h. The solvent was evaporated off and the residue dried under vacuum to remove traces of trifluoroacetic acid. The crude product was used in the next step without further purification. Yield: quantitative

後処理

  1. customthe resulting reaction mixture
  2. customThe solvent was evaporated off
  3. customthe residue dried under vacuum
  4. customto remove traces of trifluoroacetic acid
  5. customThe crude product was used in the next step without further purification

出典と根拠

ORDレコード
ord-b0de5525e311437eb2cd016bd7b2640e
出典データセット
uspto-grants-2012_09
特許番号
US08268814B2

反応ノート

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