Trifluoroacetic acid → 2-(Pyrrolidin-1-ylmethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

HRID 2388682ノート

反応式

HRID 2388682 の反応式
[N:1]1([CH2:6][C:7]2[S:15][C:14]3[CH2:13][CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10][C:9]=3[CH:8]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1.FC(F)(F)C(O)=O>ClCCl>[N:1]1([CH2:6][C:7]2[S:15][C:14]3[CH2:13][CH2:12][NH:11][CH2:10][C:9]=3[CH:8]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 86635667tert-Butyl 2-(pyrrolidin-1-ylmethyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-carboxylate

生成物 1

HCID 177966112-(Pyrrolidin-1-ylmethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
0 °C

実験手順

tert-Butyl 2-(pyrrolidin-1-ylmethyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-carboxylate (0.235 mmol) was dissolved in dichloromethane and cooled to 0° C. Trifluoroacetic acid (2 ml/mmol) was added and the reaction mixture stirred for 2 h. The solvent was completely evaporated and kept under the high vacuum to give the desired product which was used in the next step without further purification. Yield: quantitative

後処理

  1. customThe solvent was completely evaporated

出典と根拠

ORDレコード
ord-353fc89a004443b0a556fd6dd4587b61
出典データセット
uspto-grants-2012_09
特許番号
US08268814B2

反応ノート

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