Trifluoroacetic acid → 2-(Piperidin-1-ylmethyl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine
反応式
[N:1]1([CH2:7][C:8]2[S:9][C:10]3[CH2:11][N:12](C(OC(C)(C)C)=O)[CH2:13][CH2:14][C:15]=3[N:16]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.FC(F)(F)C(O)=O>ClCCl>[N:1]1([CH2:7][C:8]2[S:9][C:10]3[CH2:11][NH:12][CH2:13][CH2:14][C:15]=3[N:16]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1参加物
4
実験手順
To a cooled (0° C.) solution of tert-butyl 2-(piperidin-1-ylmethyl)-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate (0.534 mmol) in dichloromethane (3 ml) was added trifluoroacetic acid (1 ml) and reaction mixture was stirred at room temperature for 2 h. Solvent was evaporated under reduced pressure and residue was azeotroped twice with dichloromethane and used in the next step.
後処理
- additionwas added
- customSolvent was evaporated under reduced pressure and residue
- customwas azeotroped twice with dichloromethane
出典と根拠
- ORDレコード
- ord-54b9509cbd18448f9b95f25ec90d1251
- 出典データセット
- uspto-grants-2012_09
- 特許番号
- US08268814B2
反応ノート
読み込み中…