Thionyl Chloride → 3,5-Dichloropyridine-4-carbon chloride
反応式
[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Cl:11])[C:7]=1[C:8](O)=[O:9].S(Cl)([Cl:14])=O>C(Cl)Cl.CN(C=O)C>[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Cl:11])[C:7]=1[C:8]([Cl:14])=[O:9]参加物
5
反応条件
- 温度
- 50 °C
実験手順
3,5-Dichloropyridine-4-carboxylic acid (0.5 g, 2.6 mmol; Reference Example 1) was dissolved in CH2Cl2 (1.75 mL) and DMF (50 μL). Thionyl chloride (0.21 mL, 2.86 mL) was added and the reaction mixture was heated at 50° C. for 20 h. The residue was concentrated in vacuo. The formation of the acid chloride was observed by TLC (50% EtOAc/hexane) and the crude 3,5-dichloropyridine-4-carboxylic acid chloride was used in Step E without further purification.
後処理
- concentrationThe residue was concentrated in vacuo
- customthe crude 3,5-dichloropyridine-4-carboxylic acid chloride was used in Step E without further purification
出典と根拠
- ORDレコード
- ord-82bcd2e31e4742e288da7ae9c3316792
- 出典データセット
- uspto-grants-2005_02
- 特許番号
- US06855708B2
反応ノート
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