HCID 86619885、化合物 → 1,2,3,4-Tetrahydroisoquinoline-7-sulfonamide

HRID 2388841ノート

反応式

HRID 2388841 の反応式
C([NH:5][S:6]([C:9]1[CH:18]=[C:17]2[C:12]([CH2:13][CH2:14][N:15](C(=O)C(F)(F)F)[CH2:16]2)=[CH:11][CH:10]=1)(=[O:8])=[O:7])(C)(C)C>C(O)(C(F)(F)F)=O>[CH2:16]1[C:17]2[C:12](=[CH:11][CH:10]=[C:9]([S:6]([NH2:5])(=[O:7])=[O:8])[CH:18]=2)[CH2:13][CH2:14][NH:15]1

参加物

3

反応物 1

HCID 86619885HCID 86619885、化合物2 回

生成物 1

HCID 52261,2,3,4-Tetrahydroisoquinoline-7-sulfonamide

試薬・触媒・溶媒 1

HCID 6422Trifluoroacetic acid溶媒

実験手順

N-(tert-Butyl)-2-(trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide (the product from step i), 1.78 g) was dissolved in TFA and stirred at room temperature for 96 h. The reaction was reduced in vacuo and the residue purified by column chromatography on silica gel 50% EtOAc/50% iso-hexane to give the subtitle compound as a white solid. Yield: 0.65 g

後処理

  1. customthe residue purified by column chromatography on silica gel 50% EtOAc/50% iso-hexane

出典と根拠

ORDレコード
ord-dad070b6548e4e229595b46ac85a0933
出典データセット
uspto-grants-2012_09
特許番号
US08269002B2

反応ノート

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