Methanol → 4-Chloro-2-[(3-chloro-2-fluorobenzyl)thio]-6-methoxypyrimidine
反応式
[Cl:1][C:2]1[CH:7]=[C:6](Cl)[N:5]=[C:4]([S:9][CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([Cl:17])[C:12]=2[F:18])[N:3]=1.[H-].[Na+].[CH3:21][OH:22]>>[Cl:1][C:2]1[CH:7]=[C:6]([O:22][CH3:21])[N:5]=[C:4]([S:9][CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([Cl:17])[C:12]=2[F:18])[N:3]=1参加物
4
実験手順
The subtitle compound was prepared according to the procedure outlined in example 35 Step (i) using 4,6-dichloro-2-[(3-chloro-2-fluorobenzyl)thio]pyrimidine (prepared according to patent WO 2004/011443) (0.65 g), methanol (8 mL) and 60% sodium hydride (88 mg). Yield: 0.57 g.
出典と根拠
- ORDレコード
- ord-c07ba6f46a6d49f4acb2b576bbc48aca
- 出典データセット
- uspto-grants-2012_09
- 特許番号
- US08269002B2
反応ノート
読み込み中…