5-(Diphenylmethyl)-1-[3-(3-hydroxyphenyl)propyl]pyridin-2(1H)-one → 5-(Diphenylmethyl)-1-[3-(3-hydroxyphenyl)propyl]piperidin-2-one
反応式
[C:1]1([CH:7]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[C:8]2[CH:9]=[CH:10][C:11](=[O:24])[N:12]([CH2:14][CH2:15][CH2:16][C:17]3[CH:22]=[CH:21][CH:20]=[C:19]([OH:23])[CH:18]=3)[CH:13]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>CCO.O=[Pt]=O>[C:25]1([CH:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[CH:8]2[CH2:13][N:12]([CH2:14][CH2:15][CH2:16][C:17]3[CH:22]=[CH:21][CH:20]=[C:19]([OH:23])[CH:18]=3)[C:11](=[O:24])[CH2:10][CH2:9]2)[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1参加物
4
実験手順
5-(Diphenylmethyl)-1-[3-(3-hydroxyphenyl)propyl]pyridin-2(1H)-one (1 g) in EtOH (20 mL) was added dioxoplatinum (70 mg) at ambient temperature and the mixture was stirred at ambient temperature for 1 day under hydrogen atmosphere. The mixture was filtered through a bed of celite. The filtrate was evaporated in vacuo. The residue was purified by silica gel column chromatography (n-hexane:EtOAc=1:3) to afford 5-(diphenylmethyl)-1-[3-(3-hydroxyphenyl)propyl]piperidin-2-one (550 mg) as a yellow oil.