Sodium Iodide → Ethyl [3-(3-iodopropyl)phenoxy]acetate

HRID 2389354ノート

反応式

HRID 2389354 の反応式
CS(O[CH2:6][CH2:7][CH2:8][C:9]1[CH:10]=[C:11]([CH:19]=[CH:20][CH:21]=1)[O:12][CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15])(=O)=O.[I-:22].[Na+].CCOC(C)=O>CC(C)=O>[I:22][CH2:6][CH2:7][CH2:8][C:9]1[CH:10]=[C:11]([CH:19]=[CH:20][CH:21]=1)[O:12][CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15]

参加物

5

反応物 3

HCID 5238Sodium IodideHCID 8857Ethyl AcetateHCID 86637907Ethyl (3-{3-[(methylsulfonyl)oxy]propyl}phenoxy)acetate

生成物 1

HCID 86637892Ethyl [3-(3-iodopropyl)phenoxy]acetate収率 83.2%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

To a solution of ethyl (3-{3-[(methylsulfonyl)oxy]propyl}phenoxy)acetate (155 g) in acetone (1.55 L) was added sodium iodide (293.7 g) at ambient temperature and the mixture was stirred at the same temperature for 18 hours. EtOAc (1 L) was added to the mixture at ambient temperature and the resulting mixture was washed successively with water and brine. The organic layer was dried over anhydrous MgSO4, filtered and evaporated in vacuo to afford ethyl [3-(3-iodopropyl)phenoxy]acetate (142 g) as a red oil.

後処理

  1. washthe resulting mixture was washed successively with water and brine
  2. dry with materialThe organic layer was dried over anhydrous MgSO4
  3. filtrationfiltered
  4. customevaporated in vacuo

出典と根拠

ORDレコード
ord-b3e8e004cf4e4ddf9e6d9b2e2cf54fda
出典データセット
uspto-grants-2012_09
特許番号
US08273745B2

反応ノート

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