Ethyl Acetate → HCID 59312979、化合物

HRID 2389738ノート

反応式

HRID 2389738 の反応式
Cl[C:2]1[N:7]2[CH:8]=[CH:9][N:10]=[C:6]2[CH:5]=[C:4]([C:11]2[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][C:12]=2[Cl:18])[N:3]=1.[C:19]([NH:26][CH2:27][CH2:28][NH2:29])([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20].C(N(C(C)C)CC)(C)C.C(OCC)(=O)C>CS(C)=O.O>[Cl:18][C:12]1[CH:13]=[C:14]([Cl:17])[CH:15]=[CH:16][C:11]=1[C:4]1[N:3]=[C:2]([NH:29][CH2:28][CH2:27][NH:26][C:19](=[O:20])[O:21][C:22]([CH3:24])([CH3:23])[CH3:25])[N:7]2[CH:8]=[CH:9][N:10]=[C:6]2[CH:5]=1

参加物

7

反応物 4

HCID 8857Ethyl AcetateHCID 81531DiisopropylethylamineHCID 187201N-BOC-ethylenediamineHCID 59312932HCID 59312932、化合物

生成物 1

HCID 59312979HCID 59312979、化合物

試薬・触媒・溶媒 2

HCID 679Dimethyl Sulfoxide溶媒HCID 962Water溶媒

反応条件

温度
120 °C

実験手順

3.0 g (10.05 mmol) of 5-chloro-7-(2,4-dichlorophenyl)imidazo[1,2-c]pyrimidine, 2.41 g (15.07 mmol) of N-Boc-ethylenediamine and 3.89 g (30.15 mmol) of diisopropylethylamine are dissolved in 50 ml of DMSO and heated at 120° C. for 16 h. Ethyl acetate and water are added, and the removed organic phase is washed twice more with water. The organic phase is dried with magnesium sulphate. Removal of the solvent results in 4.49 g (99% of theory) of product.

後処理

  1. washthe removed organic phase is washed twice more with water
  2. dry with materialThe organic phase is dried with magnesium sulphate
  3. customRemoval of the solvent
  4. customresults in 4.49 g (99% of theory) of product

出典と根拠

ORDレコード
ord-bab4e014337046daa45b89567d332ae6
出典データセット
uspto-grants-2012_09
特許番号
US08273752B2

反応ノート

読み込み中…