4-Pyrimidinamine, 2,6-dichloro- → HCID 59313150、化合物

HRID 2389771ノート

反応式

HRID 2389771 の反応式
Cl[C:2]1[N:7]=[C:6]([NH2:8])[CH:5]=[C:4]([Cl:9])[N:3]=1.[NH2:10][CH2:11][CH2:12][NH:13][C:14]1[N:19]=[CH:18][C:17]([C:20]#[N:21])=[CH:16][CH:15]=1>C(#N)C>[NH2:8][C:6]1[CH:5]=[C:4]([Cl:9])[N:3]=[C:2]([NH:10][CH2:11][CH2:12][NH:13][C:14]2[N:19]=[CH:18][C:17]([C:20]#[N:21])=[CH:16][CH:15]=2)[N:7]=1

参加物

4

反応物 2

HCID 823874-Pyrimidinamine, 2,6-dichloro-HCID 113694056-[(2-Aminoethyl)amino]pyridine-3-carbonitrile

生成物 1

HCID 59313150HCID 59313150、化合物

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

10.3 g (63 mmol) of 2,6-dichloropyrimidine-4-amine and 10.22 g (63 mmol) of 6-[(2-aminoethyl)amino]pyridine-3-carbonitrile are dissolved in 164 ml acetonitrile and heated under reflux conditions for 24 h. After cooling, the major amount of the precipitated product is filtered off with suction. 11.9 g (50% of theory) of the product are obtained as a solid.

後処理

  1. temperatureheated under reflux conditions for 24 h
  2. temperatureAfter cooling
  3. filtrationthe major amount of the precipitated product is filtered off with suction
  4. custom11.9 g (50% of theory) of the product are obtained as a solid

出典と根拠

ORDレコード
ord-6b7e3353eea14573bf13538bbcbd7bd1
出典データセット
uspto-grants-2012_09
特許番号
US08273752B2

反応ノート

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