Methyl iodide → (3-hydroxypyridin-2-yl)-N,N,N-trimethylmethanaminium iodide
反応式
[CH3:1][N:2]([CH2:4][C:5]1[C:10]([OH:11])=[CH:9][CH:8]=[CH:7][N:6]=1)[CH3:3].[I:12][CH3:13]>CC(C)=O>[I-:12].[OH:11][C:10]1[C:5]([CH2:4][N+:2]([CH3:13])([CH3:1])[CH3:3])=[N:6][CH:7]=[CH:8][CH:9]=1参加物
4
実験手順
To a solution of 2-[(dimethylamino)methyl]pyridin-3-ol (207 g, 1.37 mol) in acetone (2000 mL) was added dropwise iodomethane (778 g, 5.48 mol) under ice-cooling, and the mixture was stirred at room temperature for 3 hr. The resulting crystals were collected by filtration to give the title compound (369 g, yield 92%).
後処理
- temperaturecooling
- filtrationThe resulting crystals were collected by filtration
出典と根拠
- ORDレコード
- ord-284a51039d62448186ac07493290f9ad
- 出典データセット
- uspto-grants-2012_09
- 特許番号
- US08273761B2
反応ノート
読み込み中…