Hydrochloric Acid → Erlotinib Hydrochloride

HRID 238993

反応式

HRID 238993 の反応式
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:17][CH2:18][CH2:19][O:20][CH3:21])=[C:9]([O:12][CH2:13][CH2:14][O:15][CH3:16])[CH:10]=2)[N:5]=[CH:4][N:3]=1.[NH2:22][C:23]1[CH:24]=[C:25]([C:29]#[CH:30])[CH:26]=[CH:27][CH:28]=1.Cl>O>[CH3:16][O:15][CH2:14][CH2:13][O:12][C:9]1[CH:10]=[C:11]2[C:2]([NH:22][C:23]3[CH:28]=[CH:27][CH:26]=[C:25]([C:29]#[CH:30])[CH:24]=3)=[N:3][CH:4]=[N:5][C:6]2=[CH:7][C:8]=1[O:17][CH2:18][CH2:19][O:20][CH3:21].[ClH:1]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 104682Benzenamine, 3-ethynyl-HCID 112899424-Chloro-6,7-bis(2-methoxyethoxy)quinazoline

生成物 1

HCID 176871Erlotinib Hydrochloride収率 88.8%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
27.5 °C

実験手順

5.0 g of 4-chloro-6,7-bis (2-methoxyethoxy) quinazoline was suspended in 75 ml water and 2.55 g of 3-aminophenyl acetylene was charged at 25-30° C. Further 1.0 ml 50% hydrochloric acid was added. The reaction mass was stirred at 25-30° C. for 2 hours. The solid obtained was filtered and washed with water. The product was dried at 40-45° C. to obtain 6.1 g of erlotinib hydrochloride.

後処理

  1. customThe solid obtained
  2. filtrationwas filtered
  3. washwashed with water
  4. customThe product was dried at 40-45° C.

出典と根拠

ORDレコード
ord-aa922a47c9354357b4c91855f1dc64d8
出典データセット
uspto-grants-2014_02
特許番号
US08642758B2

関連ノート

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