関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Toluene | HCID 1140 | — |
| 反応物 | Benzenamine, 3-ethynyl- | HCID 104682 | — |
| 反応物 | 4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline | HCID 11289942 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | Erlotinib Hydrochloride | HCID 176871 | 91.9% |
反応手順
1.98 Kg of 4-chloro-6,7-bis (2-methoxyethoxy) quinazoline was suspended in 30 litres of acetonitrile and 10 litres of toluene and 1.0 Kg of 3-aminophenyl acetylene was charged at 25-30° C. and hydrochloric acid was added. The reaction mass was heated and stirred at 35-40° C. for 6 hours. The solid obtained was filtered and washed with a mixture of acetonitrile and toluene. The product was dried at 38-40° C. to obtain 2.5 Kg of erlotinib hydrochloride.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08642758B2 |
|---|
| 出典データセット | uspto-grants-2014_02 |
|---|
| ORD ID | ord-6027599214704f5aafedec897e1eb7d8 |
|---|
| 出典メモ | uspto-grants-2014_02 |
|---|
