反应详情

温度

37.5 °C

1.98 Kg of 4-chloro-6,7-bis (2-methoxyethoxy) quinazoline was suspended in 30 litres of acetonitrile and 10 litres of toluene and 1.0 Kg of 3-aminophenyl acetylene was charged at 25-30° C. and hydrochloric acid was added. The reaction mass was heated and stirred at 35-40° C. for 6 hours. The solid obtained was filtered and washed with a mixture of acetonitrile and toluene. The product was dried at 38-40° C. to obtain 2.5 Kg of erlotinib hydrochloride.

1. temperatureThe reaction mass was heated
2. customThe solid obtained
3. filtrationwas filtered
4. washwashed with a mixture of acetonitrile and toluene
5. customThe product was dried at 38-40° C.