Hydrochloric Acid → (3-Chloro-2-methylphenyl)methanol
反応式
[Cl:1][C:2]1[C:3]([CH3:11])=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5](O)=[O:6].Cl>C1COCC1>[Cl:1][C:2]1[C:3]([CH3:11])=[C:4]([CH:8]=[CH:9][CH:10]=1)[CH2:5][OH:6]参加物
4
実験手順
To a solution of 1.70 g of 3-chloro-2-methylbenzoic acid in 20 mL of THF was added dropwise 20 mL of a borane/THF complex under ice-cooling, followed by stirring at room temperature for 2 hours. After completion of the reaction, 1 N hydrochloric acid was added to the reaction liquid, followed by extraction with chloroform. The organic layer was washed with saturated brine, dried over anhydrous sodium sulfate and then concentrated under reduced pressure to obtain 1.52 g (yield 97%) of a title compound as a white crystal.
後処理
- temperaturecooling
- additionwas added to the reaction liquid
- extractionfollowed by extraction with chloroform
- washThe organic layer was washed with saturated brine
- dry with materialdried over anhydrous sodium sulfate
- concentrationconcentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-f408fc813bcc47139652cd15c906a7da
- 出典データセット
- uspto-grants-2012_09
- 特許番号
- US08273766B2
反応ノート
読み込み中…