Water → 3-Chloro-2-methylbenzylamine

HRID 2390034ノート

反応式

HRID 2390034 の反応式
[Cl:1][C:2]1[C:3]([CH3:20])=[C:4]([CH:17]=[CH:18][CH:19]=1)[CH2:5][N:6]1C(=O)C2=CC=CC=C2C1=O.O.NN.O>CO>[Cl:1][C:2]1[C:3]([CH3:20])=[C:4]([CH:17]=[CH:18][CH:19]=1)[CH2:5][NH2:6]

参加物

5

反応物 3

HCID 962WaterHCID 24654Hydrazine hydrate (1:1)HCID 59323393N-(3-chloro-2-methylbenzyl)phthalimide

生成物 1

HCID 27576713-Chloro-2-methylbenzylamine収率 100.3%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
80 °C

実験手順

1.15 g of N-(3-chloro-2-methylbenzyl)phthalimide was dissolved in 20 mL of methanol, and 5 mL of hydrazine monohydrate was added thereto at room temperature. Thereafter, it was warmed to 80° C., followed by continuously reacting overnight. After completion of the reaction, the reaction liquid was left to be cooled, and water was added thereto, followed by extraction with chloroform. The organic layer was washed with saturated brine, dried over anhydrous sodium sulfate and then concentrated under reduced pressure to obtain 628 mg (yield 100%) of a title compound as a colorless clear oily substance.

後処理

  1. customat room temperature
  2. customAfter completion of the reaction
  3. customthe reaction liquid
  4. waitwas left
  5. temperatureto be cooled
  6. extractionfollowed by extraction with chloroform
  7. washThe organic layer was washed with saturated brine
  8. dry with materialdried over anhydrous sodium sulfate
  9. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-cba0ac32b7984915918b29b89474e363
出典データセット
uspto-grants-2012_09
特許番号
US08273766B2

反応ノート

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